27 articles - From Friday Sep 27 2024 to Friday Oct 04 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Liver Transpl |
|---|
Immunosuppression protocols for emerging oncological indications in liver transplantation: A systematic review and pooled analysis. This approach may be particularly useful in patients with cholangiocarcinoma and CRLM, in whom tumor recurrence is the main cause of death. We propose a tool for reporting immunosuppression protocols which could be implemented in future transplant oncology studies. |
| Pancreatology |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
Folate and cobalamin status, indicators, modulators, interactions and reference ranges from early pregnancy until birth: The Reus-Tarragona Birth Cohort Study. Suboptimal early pregnancy folate or cobalamin status affected47.4% and 7.3% of the participants, respectively. The MTHFR 677TT genotype consistently predicted folate status throughout pregnancy. Smoking and BMI were negatively associated with cobalamin status throughout pregnancy. Clinical trial registry number and website where it was obtained NCT01778205. . |
Longitudinal Study of Seafood and Fish Oil Supplement Intake and Risk of Persistent Tinnitus. Regular consumption of tuna fish, light-meat fish or shellfish is associated with lower risk of developing persistent tinnitus in females. Fish oil supplement use is associated with higher risk. |
| Inflamm Bowel Dis |
A Review of Cutaneous Extraintestinal Manifestations of Inflammatory Bowel Disease in Skin of Color. This review aims to describe the cutaneous manifestations of IBD in a wide range of skin tones with several examples to improve awareness. With further awareness, this review will enable to provide equitable care to IBD patients with cutaneous EIMs. |
Ileoanal Pouch-Related Fistulas: A Narrative Review. Fistulas associated with anastomotic complications, technical surgical issues, and cryptoglandular fistulas warrant surgical management. On the other hand, fistulas associated with inflammation are preferentially managed with biologics or small molecules. |
Targeting NCAPD2 as a Therapeutic Strategy for Crohn's Disease: Implications for Autophagy and Inflammation. Our results show that NCAPD2 suppresses autophagy and worsens intestinal inflammation by modulating mTOR signaling and impacting the NF-κB pathway, suggesting a critical role in CD progression. Targeting NCAPD2 could be a promising therapeutic approach to stop CD advancement. |
| J Crohns Colitis |
Crohn's disease and ulcerative colitis share two molecular subtypes with different mechanisms and drug response. This study discovered and validated a robust transcriptome-based molecular classification shared by CD and UC and built a 20-gene classifier. Because two subtypes have different molecular mechanisms and drug response, our classification may aid interpretation of heterogeneous molecular and clinical information in IBD patients. |
The circulating methylome in childhood-onset inflammatory bowel disease. Passive smoking exposure is associated with the development of UC rather than CD contrary to previous findings. These data provide new insights into epigenetic alterations in IBD and illustrate the reproducibility and translational potential of epigenome-wide association studies in complex diseases. |
The intestinal mucin isoform landscape reveals region-specific biomarker panels for inflammatory bowel disease patient stratification. We unveiled region-specific mucin RNA isoform panels capturing the heterogeneity of the IBD patient population and showing great potential to indicate barrier function in IBD patients. |
| Liver Transpl |
Analysis of treatment benefits and prognostic factors for Post-Transplant hepatocellular carcinoma recurrence in a large Euro-American-Asian cohort. Curative-intent treatments should be advocated for patients with post-transplant recurrence whenever possible. Prognostic factors linked to aggressive tumor biology significantly influence survival. Advancements in HCC management have improved survival outcomes over the past five years. |
Less is more: The use of a single biodegradable stenting to treat biliary anastomotic strictures in pediatric liver transplantation. The use of biodegradable stents stents could be good option for treating anastomotic biliary strictures in pediatric liver transplant patients, with our series showing a success rate of over 90% and an average follow-up of 43.9 months. |
Marked variation in disease acuity and outcomes on the liver transplant waiting list by sociodemographic characteristics. In the US, residence in areas of high socioeconomic disadvantage is significantly associated with higher MELD-NA at the time of wait listing among Hispanic White candidates. In addition, residence in areas of high socioeconomic disadvantage was associated with a higher risk of death or removal from the wait list and lower chances of receiving a liver transplant after wait list placement, particularly among Non-Hispanic White candidates and older candidates. |
Takotsubo cardiomyopathy following liver transplantation - a multicenter cohort study. TCM following LT is associated with a significant reduction in LVEF, however the majority of patients recover LVEF to > 50% with minimal perioperative mortality. Importantly, follow-up assessment of LVEF has significant implications as lack of recovery is associated with worse OS. |
Value of factor v in the diagnosis of early graft dysfunction after liver transplantation. internal validation. Patients meeting both criteria had a 74-fold increased risk of graft loss, with most losses occurring within the first week, and a median survival of 4 days. These findings suggest that Factor V and ALT on postoperative day 2 are reliable early markers for predicting graft loss, enabling risk stratification and guiding critical decisions regarding early retransplantation in the immediate postoperative period. |
| Pancreas |
| Pancreatology |
Efficiency evaluation of dual-energy CT to predict the postoperative early recurrence of pancreatic ductal adenocarcinoma. DECT quantitative parameters allow for the noninvasive prediction of postoperative ER in patients with PDAC, and the combination of DECT parameters and basic CT features shows a high prediction efficiency. Our model can help to identify patients with high-risk factors to guide preoperative decision making. |
Oral high-carbohydrate solution as an alternative dietary modality in patients with acute pancreatitis. In patients with AP, OCS diet was associated with a lower rate of recurrent postprandial pain compared to a CD. Thus, OCS appears to be a beneficial dietary alternative for initial management of AP. |
Prediction of pancreatic cancer in patients with new onset hyperglycemia: A modified ENDPAC model. The modified ENDPAC model targets a broader population and thus identifies more high-risk patients for cancer screening. The differential performance needs to be considered when the model is applied to non-white population. |
Prevalence and spectrum of germline pathogenic variants in cancer susceptibility genes among mexican patients with exocrine pancreatic cancer. We identified a significant frequency of actionable germline PVs in Mexicans with PC, wherein the majority were in a broad spectrum of genes associated with the homologous recombination DNA repair mechanism. Most pancreatic cancer associated PVs were detected in non-BRCA genes, so our findings support the recommendation of multigene panel testing for genetic cancer risk assessment of Mexican individuals with PC. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
|---|
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
|---|
| Liver Transpl |